Petfood Industry - January 2020 - 18

18 | www.PetfoodIndustry.com

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DISSECTING DCM: HOW GENETICS CAN IMPACT CANINE NUTRITION

Familial history (i.e., breeding pairs) is counted as a
strong risk factor. Progress has continued to identify specific genes to explain genetic susceptibility
to disease. Diseases are complex in their etiology,
causing some to believe that genetic architecture
must be multifactorial rather than embracing genetic
predisposition alone. However, does the literature
suggest that genetic predisposition of DCM impairs
specific metabolic pathways involved in nutrition? 
Dogs often have been used in the study of DCM in
humans to help identify the potential genetic markers
associated with the disease. Dogs frequently are
selected through breeding for therapy, hunting, speed,
agility, endurance, coat-condition, color, shape and
temperament.
Gilliam (2016) sequenced the complete genome of
145 dogs from 69 breeds with various inherited canine
diseases, most of which were inherited recessively. DCM
segregates in the Standard Schnauzer showed a pattern
consistent with an autosomal recessive mode of inheritance. An additional 753 Standard Schnauzers were
examined, with 21 of these having DCM (2.8%). Twenty
of these 21 DCM-dogs had a RBM20 deletion allele
(similar to humans with DCM). All the other dogs were
DCM-free and did not have the RBM deletion allele.
Rishniw (2011) completed genome-wide association studies to identify several gene candidates for

Reduction.

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Pappas 225 DPE/TPE

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canine heart disease. Candidate genes identified in
human DCM failed to identify similar genes in DCM
in Doberman Pinschers; however, there was involvement of a mitochondrial gene associated with glucose
metabolism (pyruvate dehydrogenase kinase) previously unrecognized in human DCM cases.
In 2012, Ito reported that the molecular mechanisms of taurine depletion-related cardiomyopathy
remained unclear, but Mozaffari (1986) demonstrated
taurine depletion altered myocardial carbohydrate
metabolism. This involved a specific protein in the
mitochondria that transformed pyruvate to acetylCoA, which was identified as pyruvate dehydrogenase
kinase identified in DCM genetic evaluations.

Could these pathways be further
impaired through improper
nutritional regimen?
Over 40% to 50% of dogs are overweight and well
over 15% are obese. This suggests that consumers are
feeding more than 30% to as high as 50% more calories
through treats, chews, rawhides, scraps, supplements,
toppers, etc. This over-feeding will be addressed in
a future article, but it is safe to say overall feeding
regimens are not complete and balanced even when
the commercial dog foods offered are. A food regimen
with incomplete fortification and imbalanced nutrients

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January 2020

© 2019 Pappas Inc.

Industry


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Petfood Industry - January 2020

Table of Contents for the Digital Edition of Petfood Industry - January 2020

Petfood Industry - January 2020
Contents
DCM and grain-free pet food: What will 2020 bring?
Speaking of…
News and Calendar
Smalls takes cat-first approach to customized pet food
Quality, sustainability to dominate 2020 pet food trends
Dissecting DCM: How genetics can impact canine nutrition
China’s 2019 urban pets consumer market hits 202.4B yuan
Combination feeding a popular option for pet parents
Petfood Forum Asia highlights pet food sustainability
CBD in pet foods: Has anything changed with legal status?
Onions and garlic offer flavor in the right amounts
Cat owners want first-class citizenship for their pets
New Products
Marketplace
Advertiser’s Index
Petfood Industry - January 2020 - CT1
Petfood Industry - January 2020 - CT2
Petfood Industry - January 2020 - Petfood Industry - January 2020
Petfood Industry - January 2020 - Cover2
Petfood Industry - January 2020 - 1
Petfood Industry - January 2020 - Contents
Petfood Industry - January 2020 - 3
Petfood Industry - January 2020 - DCM and grain-free pet food: What will 2020 bring?
Petfood Industry - January 2020 - 5
Petfood Industry - January 2020 - Speaking of…
Petfood Industry - January 2020 - CT3
Petfood Industry - January 2020 - CT4
Petfood Industry - January 2020 - News and Calendar
Petfood Industry - January 2020 - Smalls takes cat-first approach to customized pet food
Petfood Industry - January 2020 - 9
Petfood Industry - January 2020 - 10
Petfood Industry - January 2020 - 11
Petfood Industry - January 2020 - Quality, sustainability to dominate 2020 pet food trends
Petfood Industry - January 2020 - 13
Petfood Industry - January 2020 - 14
Petfood Industry - January 2020 - 15
Petfood Industry - January 2020 - Dissecting DCM: How genetics can impact canine nutrition
Petfood Industry - January 2020 - 17
Petfood Industry - January 2020 - 18
Petfood Industry - January 2020 - 19
Petfood Industry - January 2020 - China’s 2019 urban pets consumer market hits 202.4B yuan
Petfood Industry - January 2020 - 21
Petfood Industry - January 2020 - Combination feeding a popular option for pet parents
Petfood Industry - January 2020 - 23
Petfood Industry - January 2020 - 24
Petfood Industry - January 2020 - 25
Petfood Industry - January 2020 - 26
Petfood Industry - January 2020 - 27
Petfood Industry - January 2020 - Petfood Forum Asia highlights pet food sustainability
Petfood Industry - January 2020 - 29
Petfood Industry - January 2020 - CBD in pet foods: Has anything changed with legal status?
Petfood Industry - January 2020 - 31
Petfood Industry - January 2020 - 32
Petfood Industry - January 2020 - 33
Petfood Industry - January 2020 - Onions and garlic offer flavor in the right amounts
Petfood Industry - January 2020 - 35
Petfood Industry - January 2020 - 36
Petfood Industry - January 2020 - 37
Petfood Industry - January 2020 - Cat owners want first-class citizenship for their pets
Petfood Industry - January 2020 - 39
Petfood Industry - January 2020 - 40
Petfood Industry - January 2020 - 41
Petfood Industry - January 2020 - New Products
Petfood Industry - January 2020 - 43
Petfood Industry - January 2020 - 44
Petfood Industry - January 2020 - 45
Petfood Industry - January 2020 - 46
Petfood Industry - January 2020 - 47
Petfood Industry - January 2020 - 48
Petfood Industry - January 2020 - 49
Petfood Industry - January 2020 - Marketplace
Petfood Industry - January 2020 - 51
Petfood Industry - January 2020 - Advertiser’s Index
Petfood Industry - January 2020 - Cover3
Petfood Industry - January 2020 - Cover4
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